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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

The growth factor-activated AGC protein kinases RSK, S6K, PKB, MSK and SGK are activated by serine/threonine phosphorylation in the activation loop and in the hydrophobic motif, C-terminal to the kinase domain. In some of these kinases, phosphorylation of the hydrophobic motif creates a specific doc...

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Detalhes bibliográficos
Main Authors: Frödin, Morten, Antal, Torben L., Dümmler, Bettina A., Jensen, Claus J., Deak, Maria, Gammeltoft, Steen, Biondi, Ricardo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129083/
https://ncbi.nlm.nih.gov/pubmed/12374740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf551
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