Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

The growth factor/insulin-stimulated AGC kinases share an activation mechanism based on three phosphorylation sites. Of these, only the role of the activation loop phosphate in the kinase domain and the hydrophobic motif (HM) phosphate in a C-terminal tail region are well characterized. We investiga...

Full description

Saved in:
Bibliographic Details
Main Authors: Hauge, Camilla, Antal, Torben L, Hirschberg, Daniel, Doehn, Ulrik, Thorup, Katrine, Idrissova, Leila, Hansen, Klaus, Jensen, Ole N, Jørgensen, Thomas J, Biondi, Ricardo M, Frödin, Morten
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864980/
https://ncbi.nlm.nih.gov/pubmed/17446865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601682
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items