Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

The growth factor/insulin-stimulated AGC kinases share an activation mechanism based on three phosphorylation sites. Of these, only the role of the activation loop phosphate in the kinase domain and the hydrophobic motif (HM) phosphate in a C-terminal tail region are well characterized. We investiga...

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Bibliographische Detailangaben
Hauptverfasser: Hauge, Camilla, Antal, Torben L, Hirschberg, Daniel, Doehn, Ulrik, Thorup, Katrine, Idrissova, Leila, Hansen, Klaus, Jensen, Ole N, Jørgensen, Thomas J, Biondi, Ricardo M, Frödin, Morten
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864980/
https://ncbi.nlm.nih.gov/pubmed/17446865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601682
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