In vivo demonstration that α-synuclein oligomers are toxic

The aggregation of proteins into oligomers and amyloid fibrils is characteristic of several neurodegenerative diseases, including Parkinson disease (PD). In PD, the process of aggregation of α-synuclein (α-syn) from monomers, via oligomeric intermediates, into amyloid fibrils is considered the disea...

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Main Authors: Winner, Beate, Jappelli, Roberto, Maji, Samir K., Desplats, Paula A., Boyer, Leah, Aigner, Stefan, Hetzer, Claudia, Loher, Thomas, Vilar, Marçal, Campioni, Silvia, Tzitzilonis, Christos, Soragni, Alice, Jessberger, Sebastian, Mira, Helena, Consiglio, Antonella, Pham, Emiley, Masliah, Eliezer, Gage, Fred H., Riek, Roland
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053976/
https://ncbi.nlm.nih.gov/pubmed/21325059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100976108
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