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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
In Parkinson’s disease and dementia with Lewy bodies, α-synuclein aggregates to form oligomers and fibrils; however, the precise nature of the toxic α-synuclein species remains unclear. A number of synthetic α-synuclein mutations were recently created (E57K and E35K) that produce species of α-synucl...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3999721/ https://ncbi.nlm.nih.gov/pubmed/24662516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu057 |
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