Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

In Parkinson’s disease and dementia with Lewy bodies, α-synuclein aggregates to form oligomers and fibrils; however, the precise nature of the toxic α-synuclein species remains unclear. A number of synthetic α-synuclein mutations were recently created (E57K and E35K) that produce species of α-synucl...

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Bibliographische Detailangaben
Hauptverfasser: Rockenstein, Edward, Nuber, Silke, Overk, Cassia R., Ubhi, Kiren, Mante, Michael, Patrick, Christina, Adame, Anthony, Trejo-Morales, Margarita, Gerez, Juan, Picotti, Paola, Jensen, Poul H., Campioni, Silvia, Riek, Roland, Winkler, Jürgen, Gage, Fred H., Winner, Beate, Masliah, Eliezer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999721/
https://ncbi.nlm.nih.gov/pubmed/24662516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu057
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