6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1

Thiopurines including 6-thioguanine ((S)G), 6-mercaptopurine and azathioprine are effective anticancer agents with remarkable success in clinical practice, especially in effective treatment of acute lymphoblastic leukemia (ALL). (S)G is understood to act as a DNA hypomethylating agent in ALL cells,...

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Hlavní autoři: Yuan, Bifeng, Zhang, Jing, Wang, Hongxia, Xiong, Lei, Cai, Qian, Wang, Tina, Jacobsen, Steven, Pradhan, Sriharsa, Wang, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049985/
https://ncbi.nlm.nih.gov/pubmed/21239472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3430
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