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Cyclophosphamide Perturbs Cytosine Methylation in Jurkat-T Cells through LSD1-mediated Stabilization of DNMT1 Protein

Aberrant cytosine methylation is known to be associated with cancer development. Here we assessed how common cancer chemotherapeutic agents perturb cytosine methylation in Jurkat-T acute lymphoblastic leukemia cells. We tested six anti-tumor agents and found that cyclophosphamide induced the most pr...

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Detalhes bibliográficos
Main Authors: Zhang, Jing, Yuan, Bifeng, Zhang, Fan, Xiong, Lei, Wu, Jiang, Pradhan, Sriharsa, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221796/
https://ncbi.nlm.nih.gov/pubmed/22007908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx2003849
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