Á lódáil...
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability
The protein lysine methyltransferase SET7 regulates DNA methyltransferase-1 (DNMT1) activity in mammalian cells by promoting degradation of DNMT1 and thus allows epigenetic changes via DNA demethylation. Here we reveal an interplay between monomethylation of DNMT1 Lys142 by SET7 and phosphorylation...
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| Main Authors: | , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048033/ https://ncbi.nlm.nih.gov/pubmed/21151116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1939 |
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