Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression

BACKGROUND: Oncogenic BRAF mutation had been considered to be a founder event in the formation of melanocytic tumours; however, we recently argued against this notion by showing marked polyclonality of BRAF mutations in acquired melanocytic nevi (Lin et al, J Natl Cancer Inst., 2009; 101:1423–7). He...

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Detalhes bibliográficos
Main Authors: Lin, J, Goto, Y, Murata, H, Sakaizawa, K, Uchiyama, A, Saida, T, Takata, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049568/
https://ncbi.nlm.nih.gov/pubmed/21224857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606072
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