Variations of BRAF mutant allele percentage in melanomas

BACKGROUND: BRAF mutations are present in 40 % of human skin melanomas. Mutated tumors with an increased percentage of BRAF mutant alleles (BRAF-M%) may have a better response to RAF/MEK inhibitors. We evaluated the BRAF-M% in melanomas, and the genetic causes of its variation. METHODS: BRAF-M% was...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Hélias-Rodzewicz, Zofia, Funck-Brentano, Elisa, Baudoux, Laure, Jung, Chan Kwon, Zimmermann, Ute, Marin, Cristi, Clerici, Thierry, Le Gall, Catherine, Peschaud, Frédérique, Taly, Valérie, Saiag, Philippe, Emile, Jean-François
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491198/
https://ncbi.nlm.nih.gov/pubmed/26141748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1515-3
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