Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level

BACKGROUND: The availability of molecular-targeted therapies for the treatment of melanoma has emphasised the need to identify mutations in target genes such as BRAF and KIT. Circulating tumour cells (CTC) are present in the peripheral blood of a significant proportion of cancer patients. METHODS: H...

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Hlavní autoři: Sakaizawa, K, Goto, Y, Kiniwa, Y, Uchiyama, A, Harada, K, Shimada, S, Saida, T, Ferrone, S, Takata, M, Uhara, H, Okuyama, R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305957/
https://ncbi.nlm.nih.gov/pubmed/22281663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.12
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