Mutation landscape in melanoma patients clinical implications of heterogeneity of BRAF mutations

BACKGROUND: The detection of V600E BRAF mutations has fundamental clinical consequences as the treatment option with BRAF inhibitors such as vemurafenib or dabrafenib yields response rates of ∼48%. Heterogeneity with respect to BRAF mutation in different metastases has been described in single cases...

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Main Authors: Heinzerling, L, Baiter, M, Kühnapfel, S, Schuler, G, Keikavoussi, P, Agaimy, A, Kiesewetter, F, Hartmann, A, Schneider-Stock, R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Molecular Diagnostics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844905/
https://ncbi.nlm.nih.gov/pubmed/24196789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.622
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