A New Small-Molecule Antagonist Inhibits Graves' Disease Antibody Activation of the TSH Receptor

CONTEXT: Graves' disease (GD) is caused by persistent, unregulated stimulation of thyrocytes by thyroid-stimulating antibodies (TSAbs) that activate the TSH receptor (TSHR). We previously reported the first small-molecule antagonist of human TSHR and showed that it inhibited receptor signaling...

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Bibliographic Details
Main Authors: Neumann, Susanne, Eliseeva, Elena, McCoy, Joshua G., Napolitano, Giorgio, Giuliani, Cesidio, Monaco, Fabrizio, Huang, Wenwei, Gershengorn, Marvin C.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Endocrine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048317/
https://ncbi.nlm.nih.gov/pubmed/21123444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-1935
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