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A New Small-Molecule Antagonist Inhibits Graves' Disease Antibody Activation of the TSH Receptor
CONTEXT: Graves' disease (GD) is caused by persistent, unregulated stimulation of thyrocytes by thyroid-stimulating antibodies (TSAbs) that activate the TSH receptor (TSHR). We previously reported the first small-molecule antagonist of human TSHR and showed that it inhibited receptor signaling...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048317/ https://ncbi.nlm.nih.gov/pubmed/21123444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-1935 |
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