An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties

We are developing an orally available small-molecule, allosteric TSH receptor (TSHR) agonist for follow-up diagnostics of patients with thyroid cancer. The agonist C2 (NCGC00161870) that we have studied so far is a racemic mixture containing equal amounts of two enantiomers, E1 and E2. As enantiomer...

Full description

Saved in:
Bibliographic Details
Published in:Front Endocrinol (Lausanne)
Main Authors: Neumann, Susanne, Padia, Umesh, Cullen, Mary Jane, Eliseeva, Elena, Nir, Eshel A., Place, Robert F., Morgan, Sarah J., Gershengorn, Marvin C.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961696/
https://ncbi.nlm.nih.gov/pubmed/27512388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2016.00105
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items