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A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor

Small molecule inverse agonists for the TSH receptor (TSHR) may be used as probes of the role of basal (or agonist-independent or constitutive) signaling and may have therapeutic potential as orally active drugs to inhibit basal signaling in patients with thyroid cancer and in some patients with hyp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Neumann, Susanne, Huang, Wenwei, Eliseeva, Elena, Titus, Steve, Thomas, Craig J., Gershengorn, Marvin C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903937/
https://ncbi.nlm.nih.gov/pubmed/20427476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0199
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