The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

We herein describe the rapid synthesis of a diverse set of dihydroquinazolin-4-ones and quinazolin-4-ones, their biological evaluation as thyroid stimulating hormone receptor (TSHR) agonists, and SAR analysis. Among the compounds screened, 8b was 60-fold more potent than the hit compound 1a, which w...

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Päätekijät: Englund, Erika E., Neumann, Susanne, Eliseeva, Elena, McCoy, Joshua G., Titus, Steven, Zheng, Wei, Southall, Noel, Shin, Paul, Leister, William, Thomas, Craig J., Inglese, James, Austin, Christopher P., Gershengorn, Marvin C., Huang, Wenwei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293179/
https://ncbi.nlm.nih.gov/pubmed/22408719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1MD00145K
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