The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

We herein describe the rapid synthesis of a diverse set of dihydroquinazolin-4-ones and quinazolin-4-ones, their biological evaluation as thyroid stimulating hormone receptor (TSHR) agonists, and SAR analysis. Among the compounds screened, 8b was 60-fold more potent than the hit compound 1a, which w...

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Autors principals: Englund, Erika E., Neumann, Susanne, Eliseeva, Elena, McCoy, Joshua G., Titus, Steven, Zheng, Wei, Southall, Noel, Shin, Paul, Leister, William, Thomas, Craig J., Inglese, James, Austin, Christopher P., Gershengorn, Marvin C., Huang, Wenwei
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293179/
https://ncbi.nlm.nih.gov/pubmed/22408719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1MD00145K
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