Synthesis and Evaluation of Quinazolin-4-ones as Hypoxia-inducible Factor-1α Inhibitors

Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this paper, we describe an efficient one-pot sequential reaction for the synthesis of quinazolin-4-one 1 analogues. The struct...

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Hauptverfasser: Huang, Wenwei, Huang, Ruili, Ramos, Matias Attene, Sakamuru, Srilatha, Englund, Erika E., Inglese, James, Austin, Christopher P., Xia, Menghang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681418/
https://ncbi.nlm.nih.gov/pubmed/21831635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.07.043
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