A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice

Because the TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment. We attempted to develop a small molecule, drug-like antagonist of TSHR signaling that is selective and active in vivo. We synthesized NCGC00242364 (ANTAG3) by...

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Autors principals: Neumann, Susanne, Nir, Eshel A., Eliseeva, Elena, Huang, Wenwei, Marugan, Juan, Xiao, Jingbo, Dulcey, Andrés E., Gershengorn, Marvin C.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2014
Matèries:
Thyroid-TRH-TSH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868809/
https://ncbi.nlm.nih.gov/pubmed/24169564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1835
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