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A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice
Because the TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment. We attempted to develop a small molecule, drug-like antagonist of TSHR signaling that is selective and active in vivo. We synthesized NCGC00242364 (ANTAG3) by...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Endocrine Society
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868809/ https://ncbi.nlm.nih.gov/pubmed/24169564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1835 |
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