Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is an effective and safe delivery of siRNA to target tissues and cells via systemic administration. While lipid nanoparticles (LNPs) composed of a cationic lipid, poly-(ethylene glycol) lipid and cholesterol, are...

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Autores principales: Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048191/
https://ncbi.nlm.nih.gov/pubmed/21179008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.282
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