Quantitative evaluation of siRNA delivery in vivo

Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy of gene silencing and siRNA uptake in the tissue. H...

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Detalhes bibliográficos
Main Authors: Pei, Yi, Hancock, Paula J., Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J., Seitzer, Jessica, Koser, Martin L., Abrams, Marc T., Xu, Yan, Kuklin, Nelly A., Burke, Paul A., Sachs, Alan B., Sepp-Lorenzino, Laura, Barnett, Stanley F.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
https://ncbi.nlm.nih.gov/pubmed/20940339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2255810
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