Quantitative evaluation of siRNA delivery in vivo

Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy of gene silencing and siRNA uptake in the tissue. H...

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Hlavní autoři: Pei, Yi, Hancock, Paula J., Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J., Seitzer, Jessica, Koser, Martin L., Abrams, Marc T., Xu, Yan, Kuklin, Nelly A., Burke, Paul A., Sachs, Alan B., Sepp-Lorenzino, Laura, Barnett, Stanley F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
https://ncbi.nlm.nih.gov/pubmed/20940339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2255810
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