Quantitative evaluation of siRNA delivery in vivo

Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy of gene silencing and siRNA uptake in the tissue. H...

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Bibliographic Details
Main Authors: Pei, Yi, Hancock, Paula J., Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J., Seitzer, Jessica, Koser, Martin L., Abrams, Marc T., Xu, Yan, Kuklin, Nelly A., Burke, Paul A., Sachs, Alan B., Sepp-Lorenzino, Laura, Barnett, Stanley F.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
https://ncbi.nlm.nih.gov/pubmed/20940339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2255810
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