Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is an effective and safe delivery of siRNA to target tissues and cells via systemic administration. While lipid nanoparticles (LNPs) composed of a cationic lipid, poly-(ethylene glycol) lipid and cholesterol, are...

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Detalhes bibliográficos
Main Authors: Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048191/
https://ncbi.nlm.nih.gov/pubmed/21179008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.282
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