The Cytoprotective Effect of N-acetyl-L-cysteine against ROS-Induced Cytotoxicity Is Independent of Its Ability to Enhance Glutathione Synthesis

2,3,5-Tris(glutathion-S-yl)-hydroquinone (TGHQ), a metabolite of hydroquinone, is toxic to renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an oxidative stress. To assist in elucidating the contribution of reactive oxygen species (ROS) to TGHQ-induced toxici...

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Bibliografske podrobnosti
Main Authors: Zhang, Fengjiao, Lau, Serrine S., Monks, Terrence J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
In Vitro Methods and Alternatives to Animals
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044202/
https://ncbi.nlm.nih.gov/pubmed/21135414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq364
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