PARP-1 Hyperactivation and Reciprocal Elevations in Intracellular Ca(2+) During ROS-Induced Nonapoptotic Cell Death

The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of renal ischemia/reperfusion injury, and many other pathological conditions. DNA strand breaks caused by ROS lead to the activation of poly(ADP-ribose)polymerase-1 (PARP-1), the excessive activation of which can...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Fengjiao, Xie, Ruiye, Munoz, Frances M., Lau, Serrine S., Monks, Terrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
In Vitro Methods and Alternatives to Animals
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081636/
https://ncbi.nlm.nih.gov/pubmed/24752504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu073
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