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PARP-1 Hyperactivation and Reciprocal Elevations in Intracellular Ca(2+) During ROS-Induced Nonapoptotic Cell Death
The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of renal ischemia/reperfusion injury, and many other pathological conditions. DNA strand breaks caused by ROS lead to the activation of poly(ADP-ribose)polymerase-1 (PARP-1), the excessive activation of which can...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4081636/ https://ncbi.nlm.nih.gov/pubmed/24752504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu073 |
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