The Cytoprotective Effect of N-acetyl-L-cysteine against ROS-Induced Cytotoxicity Is Independent of Its Ability to Enhance Glutathione Synthesis

2,3,5-Tris(glutathion-S-yl)-hydroquinone (TGHQ), a metabolite of hydroquinone, is toxic to renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an oxidative stress. To assist in elucidating the contribution of reactive oxygen species (ROS) to TGHQ-induced toxici...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Fengjiao, Lau, Serrine S., Monks, Terrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
In Vitro Methods and Alternatives to Animals
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044202/
https://ncbi.nlm.nih.gov/pubmed/21135414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq364
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