The Cytoprotective Effect of N-acetyl-L-cysteine against ROS-Induced Cytotoxicity Is Independent of Its Ability to Enhance Glutathione Synthesis

2,3,5-Tris(glutathion-S-yl)-hydroquinone (TGHQ), a metabolite of hydroquinone, is toxic to renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an oxidative stress. To assist in elucidating the contribution of reactive oxygen species (ROS) to TGHQ-induced toxici...

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Hlavní autoři: Zhang, Fengjiao, Lau, Serrine S., Monks, Terrence J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
In Vitro Methods and Alternatives to Animals
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044202/
https://ncbi.nlm.nih.gov/pubmed/21135414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq364
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