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A Dual Role for Poly(ADP-Ribose) Polymerase-1 
During Caspase-Dependent Apoptosis

2,3,5-Tris(glutathion-S-yl)hydroquinone (TGHQ), a metabolite of benzene, catalyzes the generation of reactive oxygen species (ROS) and caspase-dependent apoptosis in human promyelocytic leukemia (HL-60) cells. We now report that TGHQ induces severe DNA damage, as evidenced by DNA ladder formation an...

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Detalhes bibliográficos
Main Authors: Zhang, Fengjiao, Lau, Serrine S., Monks, Terrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: OUP 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491962/
https://ncbi.nlm.nih.gov/pubmed/22523229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs142
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