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A Dual Role for Poly(ADP-Ribose) Polymerase-1 During Caspase-Dependent Apoptosis
2,3,5-Tris(glutathion-S-yl)hydroquinone (TGHQ), a metabolite of benzene, catalyzes the generation of reactive oxygen species (ROS) and caspase-dependent apoptosis in human promyelocytic leukemia (HL-60) cells. We now report that TGHQ induces severe DNA damage, as evidenced by DNA ladder formation an...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
OUP
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491962/ https://ncbi.nlm.nih.gov/pubmed/22523229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs142 |
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