Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4(+) T cells

The mechanism of action of methotrexate (MTX) in autoimmune diseases (AID) is unclear. A pro-apoptotic effect has been demonstrated in mitogen-stimulated peripheral blood mononuclear cells (PBMC), but studies employing conventional antigens have disputed a pro-apoptotic effect. CD4(+) T helper (Th)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nielsen, C H, Albertsen, L, Bendtzen, K, Baslund, B
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2007
Gaiak:
Basic Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868870/
https://ncbi.nlm.nih.gov/pubmed/17286800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2007.03335.x
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