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Analysis of the stabilities of hexameric amyloid-β (1–42) models using Discrete Molecular Dynamics simulations

Amyloid-β (Aβ) oligomers appear to play a pivotal role in Alzheimer’s disease. A 42 residue long alloform, Aβ42, is closely related to etiology of the disease. In vitro results show evidences of hexamers; however structures of these hexamers have not been resolved experimentally. Here, we use Discre...

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Detalhes bibliográficos
Main Authors: Yun, Sijung, Yun, Sajung, Guy, H. Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040446/
https://ncbi.nlm.nih.gov/pubmed/21186130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2010.11.008
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