Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine receptor XCR1 is expressed...

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Main Authors: Lei, Yu, Ripen, Adiratna Mat, Ishimaru, Naozumi, Ohigashi, Izumi, Nagasawa, Takashi, Jeker, Lukas T., Bösl, Michael R., Holländer, Georg A., Hayashi, Yoshio, de Waal Malefyt, Rene, Nitta, Takeshi, Takahama, Yousuke
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039864/
https://ncbi.nlm.nih.gov/pubmed/21300913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102327
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