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Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca(2+) Loading Capacity and Promotes Apoptosis
Ceramides, which are membrane sphingolipids and key mediators of cell-stress responses, are generated by a family of (dihydro) ceramide synthases (Lass1–6/CerS1–6). Here, we report that brain development features significant increases in sphingomyelin, sphingosine, and most ceramide species. In cont...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039377/ https://ncbi.nlm.nih.gov/pubmed/21148554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164392 |
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