Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca(2+) Loading Capacity and Promotes Apoptosis

Ceramides, which are membrane sphingolipids and key mediators of cell-stress responses, are generated by a family of (dihydro) ceramide synthases (Lass1–6/CerS1–6). Here, we report that brain development features significant increases in sphingomyelin, sphingosine, and most ceramide species. In cont...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Novgorodov, Sergei A., Chudakova, Daria A., Wheeler, Brian W., Bielawski, Jacek, Kindy, Mark S., Obeid, Lina M., Gudz, Tatyana I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039377/
https://ncbi.nlm.nih.gov/pubmed/21148554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164392
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker