SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY

Experimental evidence supports the role of mitochondrial ceramide accumulation as a cause of mitochondrial dysfunction and brain injury after stroke. Herein, we report that SIRT3 regulates mitochondrial ceramide biosynthesis via deacetylation of ceramide synthase (CerS) 1, 2, and 6. Reciprocal immun...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Novgorodov, Sergei A., Riley, Christopher L., Keffler, Jarryd A., Yu, Jin, Kindy, Mark S., Macklin, Wendy B., Lombard, David B., Gudz, Tatyana I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722471/
https://ncbi.nlm.nih.gov/pubmed/26620563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668228
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