Novel Pathway of Ceramide Production in Mitochondria: THIOESTERASE AND NEUTRAL CERAMIDASE PRODUCE CERAMIDE FROM SPHINGOSINE AND ACYL-CoA

Reports suggest that excessive ceramide accumulation in mitochondria is required to initiate the intrinsic apoptotic pathway and subsequent cell death, but how ceramide accumulates is unclear. Here we report that liver mitochondria exhibit ceramide formation from sphingosine and palmitoyl-CoA and fr...

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Detalhes bibliográficos
Main Authors: Novgorodov, Sergei A., Wu, Bill X., Gudz, Tatyana I., Bielawski, Jacek, Ovchinnikova, Tatiana V., Hannun, Yusuf A., Obeid, Lina M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137106/
https://ncbi.nlm.nih.gov/pubmed/21613224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214866
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