Syk-dependent Phosphorylation of CLEC-2: A NOVEL MECHANISM OF HEM-IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING

The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is abolished in the absence of the tyr...

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Main Authors: Séverin, Sonia, Pollitt, Alice Y., Navarro-Nuñez, Leyre, Nash, Craig A., Mourão-Sá, Diego, Eble, Johannes A., Senis, Yotis A., Watson, Steve P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039337/
https://ncbi.nlm.nih.gov/pubmed/21098033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167502
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