Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity

Nucleoside analogs are efficacious cancer chemotherapeutics due to their incorporation into tumor cell DNA. However, they exhibit vastly different antitumor efficacies, suggesting that incorporation produces divergent effects on DNA replication. Here we have evaluated the consequences of incorporati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: O’Konek, Jessica J., Ladd, Brendon, Flanagan, Sheryl A., Im, Mike M., Boucher, Paul D., Thepsourinthone, Tico S., Secrist, John A., Shewach, Donna S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038579/
https://ncbi.nlm.nih.gov/pubmed/20004674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.11.011
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