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Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity

Nucleoside analogs are efficacious cancer chemotherapeutics due to their incorporation into tumor cell DNA. However, they exhibit vastly different antitumor efficacies, suggesting that incorporation produces divergent effects on DNA replication. Here we have evaluated the consequences of incorporati...

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Bibliografski detalji
Glavni autori: O’Konek, Jessica J., Ladd, Brendon, Flanagan, Sheryl A., Im, Mike M., Boucher, Paul D., Thepsourinthone, Tico S., Secrist, John A., Shewach, Donna S.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038579/
https://ncbi.nlm.nih.gov/pubmed/20004674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.11.011
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