Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects. Here, we describe an LXR gain-of-function system tha...

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Hlavní autoři: Hong, Cynthia, Walczak, Robert, Dhamko, Helena, Bradley, Michelle N., Marathe, Chaitra, Boyadjian, Rima, Salazar, Jon V., Tontonoz, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035689/
https://ncbi.nlm.nih.gov/pubmed/21187453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M010686
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