Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS

Inhibitors of quinone reductase-2 (NQO2; QR-2) can have anti-malarial activity and anti-tumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. To expedite the search for new natural product inhibitors of QR-2, we develop...

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Autores principales: Choi, Yongsoo, Jermihov, Katherine, Nam, Sang-Jip, Sturdy, Megan, Maloney, Katherine, Qiu, Xi, Chadwick, Lucas R., Main, Matthew, Chen, Shao-Nong, Mesecar, Andrew D., Farnsworth, Norman R., Pauli, Guido F., Fenical, William, Pezzuto, John M., van Breemen, Richard R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034444/
https://ncbi.nlm.nih.gov/pubmed/21192729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac1028424
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