Recognition of Sulfonylurea Receptor (ABCC8/9) Ligands by the Multidrug Resistance Transporter P-glycoprotein (ABCB1): FUNCTIONAL SIMILARITIES BASED ON COMMON STRUCTURAL FEATURES BETWEEN TWO MULTISPECIFIC ABC PROTEINS

ATP-sensitive K(+) (K(ATP)) channels are the target of a number of pharmacological agents, blockers like hypoglycemic sulfonylureas and openers like the hypotensive cromakalim and diazoxide. These agents act on the channel regulatory subunit, the sulfonylurea receptor (SUR), which is an ABC protein...

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Detalhes bibliográficos
Main Authors: Bessadok, Anis, Garcia, Elisabeth, Jacquet, Hélène, Martin, Solenne, Garrigues, Alexia, Loiseau, Nicolas, André, François, Orlowski, Stéphane, Vivaudou, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030360/
https://ncbi.nlm.nih.gov/pubmed/21098040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155200
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