Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies–Induced Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents glomerulonephritis in mouse models of lu...

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Bibliografiske detaljer
Main Authors: Bontscho, Julia, Schreiber, Adrian, Manz, Rudolf A., Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2011
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029906/
https://ncbi.nlm.nih.gov/pubmed/21233415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010034
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