Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies–Induced Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents glomerulonephritis in mouse models of lu...

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Autors principals: Bontscho, Julia, Schreiber, Adrian, Manz, Rudolf A., Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2011
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029906/
https://ncbi.nlm.nih.gov/pubmed/21233415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010034
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