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Neutrophil Serine Proteases Promote IL-1β Generation and Injury in Necrotizing Crescentic Glomerulonephritis

The pathogenesis of anti–neutrophil cytoplasmic antibody (ANCA)–associated necrotizing crescentic GN (NCGN) is incompletely understood. Dipeptidyl peptidase I (DPPI) is a cysteine protease required for the activation of neutrophil serine proteases (NSPs) cathepsin G, neutrophil elastase, and protein...

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Autors principals: Schreiber, Adrian, Pham, Christine T.N., Hu, Ying, Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294298/
https://ncbi.nlm.nih.gov/pubmed/22241891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010080892
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