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Phagocyte NADPH Oxidase Restrains the Inflammasome in ANCA-Induced GN
ANCA-activated phagocytes cause vasculitis and necrotizing crescentic GN (NCGN). ANCA-induced phagocyte NADPH oxidase (Phox) may contribute by generating tissue-damaging reactive oxygen species. We tested an alternative hypothesis, in which Phox restrains inflammation by downregulating caspase-1, th...
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| Veröffentlicht in: | J Am Soc Nephrol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Nephrology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310655/ https://ncbi.nlm.nih.gov/pubmed/25012177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013111177 |
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