Endothelial NF-κB Blockade Abrogates ANCA-Induced GN

ANCA-associated vasculitis (AAV) is a highly inflammatory condition in which ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis. We tested the hypothesis that endothelial NF-κB mediates necrotizing crescentic GN (NCGN) and provides a specific treatment targ...

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Publicat a:J Am Soc Nephrol
Autors principals: Choi, Mira, Schreiber, Adrian, Eulenberg-Gustavus, Claudia, Scheidereit, Claus, Kamps, Jan, Kettritz, Ralph
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2017
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661273/
https://ncbi.nlm.nih.gov/pubmed/28687535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016060690
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